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那扎替尼 Nazartinib (EGF816)

那扎替尼 Nazartinib (EGF816) 1508250-71-2
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產品信息
產品名稱:那扎替尼 Nazartinib (EGF816) 純度:98.0% min
CAS NO:1508250-71-2 溶解度:DMSO : ≥ 242 mg/mL (488.87 mM)
分子式:C26H31ClN6O2 包裝:可按客戶要求包裝
分子量:495.016 貯存:-20oC
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備注說明

Nazartinib, also known as EGF816 and NVS-816, is an orally available, irreversible, third-generation, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. EGF816 covalently binds to and inhibits the activity of mutant forms of EGFR, including the T790M EGFR mutant, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGF816 preferentially inhibits mutated forms of EGFR including T790M, a secondarily acquired resistance mutation, and may have therapeutic benefits in tumors with T790M-mediated resistance when compared to other EGFR tyrosine kinase inhibitors.

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